Note: All series are best of three games.
Eastern Conference
D.C. United vs. New England | |
| Date | Matchup | Kickoff (ET) |
| Sunday, Oct. 5 | New England at D.C. United | 8:00 p.m. (ESPN2) |
| Wednesday, Oct. 8 | D.C. United at New England | 7:30 p.m. (ESPN2 — taped at 10:30 p.m.) |
| Sunday, Oct. 12 | New England at D.C. United | Afternoon TBD if necessary |
Tampa Bay vs. Columbus | |
| Date | Matchup | Kickoff (ET) |
| Sunday, Oct. 5 | Columbus at Tampa Bay | 3:00 p.m. (Univision) |
| Wednesday, Oct. 8 | Tampa Bay at Columbus | 7:30 p.m. |
| Saturday, Oct. 11 | Columbus at Tampa Bay | 7:30 p.m. if necessary |
Western Conference
Kansas City vs. Colorado | |
| Date | Matchup | Kickoff (ET) |
| Saturday, Oct. 4 | Colorado at Kansas City | 8:30 p.m. |
| Wendnesday, Oct. 8 | Kansas City at Colorado | 9:00 p.m. |
| Sunday, Oct. 12 | Colorado at Kansas City | Afternoon TBD if necessary |
Los Angeles vs. Dallas | |
| Date | Matchup | Kickoff (ET) |
| Sunday, Oct. 5 | Dallas at Los Angeles | 7:30 p.m. |
| Wednesday, Oct. 8 | Los Angeles at Dallas | 8:30 p.m. |
| Saturday, Oct. 11 | Dallas at Los Angeles | 10:30 p.m. if necessary |
