Note: All times are Eastern. Saturday, March 20
| D.C. United at Tampa Bay | 7:00 |
| MetroStars at Miami | 8:00 |
| Kansas City at Dallas | 8:30 |
| Colorado at Los Angeles | 10:30 |
| Chicago at San Jose | 11:00 |
Saturday, March 27 | Chicago at Kansas City | 8:30 |
| Colorado at San Jose | 10:00 |
Sunday, March 28 | Columbus at MetroStars | 2:00 |
| New England at Miami | 3:00 |
| Dallas at Los Angeles | 8:00 |
Saturday, April 3 | D.C. United at MetroStars | 7:00 |
| Columbus at Tampa Bay | 7:00 |
| Chicago at Miami | 7:00 |
| New England at Kansas City | 8:30 |
| Los Angeles at San Jose | 10:00 |
Thursday, April 8 | Columbus at Los Angeles | 10:30 |
Saturday, April 10 | San Jose at Kansas City | 3:30 |
| D.C. United at New England | 7:30 |
| Dallas at Chicago | 8:00 |
| Miami at Colorado | 9:00 |
Sunday, April 11 | MetroStars at Tampa Bay | 5:00 |
Thursday, April 15 Saturday, April 17 | Columbus at New England | 7:30 |
| San Jose at D.C. United | 7:30 |
| Los Angeles at Chicago | 8:00 |
| Kansas City at Colorado | 9:00 |
Sunday, April 18 Saturday, April 24 | New England at D.C. United | 7:30 |
| Kansas City at Miami | 7:30 |
| Columbus at Dallas | 8:30 |
| San Jose at Los Angeles | 10:30 |
Sunday, April 25 | Tampa Bay at MetroStars | 1:00 |
Wednesday, April 28 | Columbus at Kansas City | 12:30 |
Friday, April 30 Saturday, May 1 | Los Angeles at MetroStars | 7:00 |
| Miami at Tampa Bay | 7:00 |
| Colorado at New England | 7:30 |
| D.C. United at Chicago | 8:00 |
Saturday, May 8 | MetroStars at D.C. United | 4:00 |
| Chicago at Tampa Bay | 7:00 |
| Miami at New England | 7:30 |
| Los Angeles at Kansas City | 8:30 |
| Colorado at Dallas | 8:30 |
Sunday, May 9 | Columbus at San Jose | 5:00 |
Saturday, May 15 | Miami at MetroStars | 7:00 |
| New England at Columbus | 7:30 |
| D.C. United at Kansas City | 8:30 |
| San Jose at Dallas | 8:30 |
| Tampa Bay at Los Angeles | 10:30 |
Sunday, May 16 Saturday, May 22 | D.C. United at Miami | 2:00 |
| Tampa Bay at Columbus | 7:30 |
| Kansas City at Chicago | 8:00 |
| MetroStars at Colorado | 9:00 |
| Dallas at San Jose | 11:00 |
Sunday, May 23 | New England at Los Angeles | 7:30 |
Wednesday, May 26 Thursday, May 27 | San Jose at Colorado | 9:30 |
Saturday, May 29 | New England at MetroStars | 7:00 |
| Tampa Bay at Miami | 7:30 |
| Los Angeles at Columbus | 7:30 |
| Chicago at D.C. United | 7:30 |
Thursday, June 3 | Colorado at San Jose | 10:30 |
Saturday, June 5 | Dallas at MetroStars | 7:00 |
| Miami at Tampa Bay | 7:00 |
| Chicago at New England | 7:30 |
| Columbus at D.C. United | 7:30 |
Sunday, June 6 | Kansas City at Los Angeles | 3:30 |
Thursday, June 10 | Miami at D.C. United | 7:30 |
Saturday, June 12 | Colorado at MetroStars | 7:00 |
| Dallas at Kansas City | 8:30 |
| Chicago at Los Angeles | 10:30 |
| Tampa Bay at San Jose | 10:30 |
Sunday, June 13 | Miami at New England | 4:00 |
| D.C. United at Columbus | 4:00 |
Wednesday, June 16 | New England at Columbus | 7:30 |
| D.C. United at Dallas | 8:30 |
Saturday, June 19 | New England at Tampa Bay | 7:00 |
| Los Angeles at D.C. United | 7:30 |
| San Jose at Chicago | 8:00 |
| Dallas at Colorado | 9:00 |
Sunday, June 20 | MetroStars at Kansas City | 1:00 |
Saturday, June 26 | Kansas City at D.C. United | 7:30 |
| San Jose at Miami | 7:30 |
| MetroStars at Columbus | 7:30 |
| New England at Dallas | 8:30 |
| Chicago at Colorado | 9:00 |
Sunday, June 27 | Los Angeles at Tampa Bay | 1:00 |
Wednesday, June 30 | Tampa Bay at MetroStars | 7:00 |
| San Jose at Columbus | 7:30 |
Friday, July 2 Saturday, July 3 | Kansas City at Tampa Bay | 7:00 |
Sunday, July 4 | *MetroStars at New England | 4:30 |
| *D.C. United at San Jose | 7:00 |
| Chicago at Dallas | 8:30 |
| Columbus at Colorado | 9:00 |
| Miami at Los Angeles | 10:30 |
*-doubleheader with Women’s World Cup; D.C.-San Jose match is at Stanford Stadium.
Wednesday, July 7 | D.C. United at Columbus | 7:30 |
| Colorado at Kansas City | 8:00 |
Thursday, July 8 | San Jose at Tampa Bay | 7:30 |
Saturday, July 10 | Colorado at D.C. United | 7:30 |
| Columbus at Miami | 7:30 |
| MetroStars at Chicago | 8:30 |
| Kansas City at Dallas | 9:00 |
Sunday, July 11 | Los Angeles at New England | 1:00 |
Saturday, July 17 | MLS All-Star Game (in San Diego) | 3:30 |
Thursday, July 22 | Tampa Bay at Kansas City | 8:00 |
Friday, July 23 Saturday, July 24 | Miami at MetroStars | 3:00 |
| Dallas at Columbus | 7:30 |
Sunday, July 25 | D.C. United at New England | 1:00 |
| Kansas City at Los Angeles | 3:30 |
| Tampa Bay at Colorado | 9:00 |
Wednesday, July 28 | Los Angeles at Colorado | 9:00 |
Thursday, July 29 Saturday, July 31 | Los Angeles at Chicago | 4:00 |
| New England at Tampa Bay | 7:00 |
| San Jose at Kansas City | 8:30 |
| Colorado at Dallas | 8:30 |
Sunday, August 1 Wednesday, August 4 | MetroStars at Dallas | 8:30 |
Thursday, August 5 | Chicago at Kansas City | 8:00 |
Friday, August 6 | New England at Colorado | 9:00 |
Saturday, August 7 | MetroStars at Miami | 7:30 |
| Los Angeles at San Jose | 10:30 |
Sunday, August 8 | Colorado at Chicago | 1:00 |
| Tampa Bay at D.C. United | 2:00 |
| Kansas City at Columbus | 6:00 |
Wednesday, August 11 | D.C. United at MetroStars | 7:00 |
Thursday, August 12 | San Jose at New England | 7:30 |
Friday, August 13 | Colorado at Tampa Bay | 7:30 |
Saturday, August 14 | Columbus at D.C. United | 4:00 |
| Kansas City at MetroStars | 7:00 |
| Dallas at Los Angeles | 10:30 |
Sunday, August 15 Wednesday, August 18 | Columbus at MetroStars | 7:00 |
| Tampa Bay at New England | 7:30 |
| Dallas at Colorado | 9:00 |
Saturday, August 21 | D.C. United at Miami | 8:00 |
| MetroStars at Los Angeles | 10:30 |
| New England at San Jose | 10:30 |
Sunday, August 22 | Chicago at Dallas | 1:00 |
| Tampa Bay at Columbus | 4:00 |
Wednesday, August 25 | New England at MetroStars | 7:00 |
| Miami at D.C. United | 7:30 |
| Kansas City at Chicago | 8:30 |
Friday, August 27 | Columbus at Tampa Bay | 7:30 |
Saturday, August 28 | New England at Chicago | 8:00 |
| Los Angeles at Dallas | 8:30 |
| D.C. United at Colorado | 9:00 |
| MetroStars at San Jose | 10:30 |
Sunday, August 29 | Miami at Kansas City | 1:00 |
Wednesday, September 1 | San Jose at Los Angeles | 10:30 |
Saturday, September 4 | Tampa Bay at New England | 7:30 |
| Dallas at D.C. United | 7:30 |
| Los Angeles at Miami | 7:30 |
| Colorado at Columbus | 7:30 |
| Kansas City at San Jose | 10:30 |
Sunday, September 5 | Chicago at MetroStars | 1:00 |
Tuesday, September 7 | Kansas City at New England | 8:00 |
Friday, September 10 | D.C. United at Tampa Bay | 7:30 |
| Kansas City at Colorado | 9:00 |
Saturday, September 11 | |
| New England at Miami | 7:30 |
| San Jose at Dallas | 8:30 |
| Chicago at Los Angeles | 10:30 |
| |
| Sunday, September 12 |
| |
| MetroStars at Columbus | 1:00 |
Friday, September 17 | Tampa Bay at Chicago | 8:30 |
Saturday, September 18 | Columbus at New England | 7:30 |
| MetroStars at D.C. United | 7:30 |
| Dallas at Kansas City | 8:30 |
| Los Angeles at Colorado | 9:00 |
Sunday, September 19 | Miami at San Jose | 5:00 |
| |
| Wednesday, September 22 |
| |
| San Jose at MetroStars | 7:30 |
Thursday, September 23 Friday, September 24 | Dallas at New England | 7:30 |
Saturday, September 25 | MetroStars at Tampa Bay | 7:00 |
| Colorado at Kansas City | 8:30 |
| D.C. United at Los Angeles | 10:30 |
Sunday, September 26 | Miami at Columbus | 1:00 |
| Chicago at San Jose | 5:00 |
Wednesday, September 29 | Colorado at Los Angeles | 10:30 |
Friday, October 1 | San Jose at Colorado | 9:00 |
Saturday, October 2 | MetroStars at New England | 7:30 |
Sunday, October 3 | Los Angeles at Dallas | 1:00 |
| Columbus at Miami | 7:30 |
Wednesday, October 6 | Tampa Bay at D.C. United | 7:30 |
| Chicago at Colorado | 9:00 |
| Kansas City at San Jose | 10:30 |
Saturday, October 9 | New England at D.C. United | 7:30 |
| Colorado at Miami | 7:30 |
| Los Angeles at Kansas City | 8:30 |
Sunday, October 10 | Chicago at Columbus | 1:00 |
| Dallas at Tampa Bay | 8:00 |
