Here is the 1999 New England Revolution schedule. Please note that all times are ET and that the schedule is subject to change.
| Date | Opponent | Time (ET) |
| Sun. March 28 | at Miami | 3:00 p.m. |
| Sat. April 3 | at Kansas City | 8:30 p.m. |
| Sat. April 10 | D.C. United | 7:30 p.m. |
| Sat. April 17 | Columbus | 7:30 p.m. |
| Sat. April 24 | at D.C. United | 7:30 p.m. |
| Sat. May 1 | Colorado | 7:30 p.m. |
| Sat. May 8 | Miami | 7:30 p.m. |
| Sat. May 15 | at Columbus | 7:30 p.m. |
| Sun. May 23 | at Los Angeles | 7:30 p.m. |
| Sat. May 29 | at MetroStars | 7:00 p.m. |
| Sat. June 5 | Chicago | 7:30 p.m. |
| Sun. June 13 | Miami | 4:00 p.m. |
| Wed. June 16 | at Columbus | 7:30 p.m. |
| Sat. June 19 | at Tampa Bay | 7:00 p.m. |
| Sat. June 26 | at Dallas | 8:30 p.m. |
| Sun. July 4 | MetroStars | 4:30 p.m. |
| Sun. July 11 | Los Angeles | 1:00 p.m. |
| Sun. July 25 | D.C. United | 1:00 p.m. |
| Sat. July 31 | at Tampa Bay | 7:00 p.m. |
| Fri. Aug. 6 | at Colorado | 9:00 p.m. |
| Thu. Aug. 12 | San Jose | 7:30 p.m. |
| Wed. Aug. 18 | Tampa Bay | 7:30 p.m. |
| Sat. Aug. 21 | at San Jose | 10:30 p.m. |
| Wed. Aug. 25 | at MetroStars | 7:00 p.m. |
| Sat. Aug. 28 | at Chicago | 8:00 p.m. |
| Sat. Sept. 4 | Tampa Bay | 7:30 p.m. |
| Tues. Sept. 7 | Kansas City | 8:00 p.m. |
| Sat. Sept. 11 | at Miami | 7:30 p.m. |
| Sat. Sept. 18 | Columbus | 7:30 p.m. |
| Fri. Sept. 24 | Dallas | 7:30 p.m. |
| Sat. Oct. 2 | MetroStars | 7:30 p.m. |
| Sat. Oct. 9 | at D.C. United | 7:30 p.m. |