Three Top 25 teams lost to unranked teams in midweek action, most notably UC Santa Barbara, which dropped its second straight game after opening with a 12-game unbeaten streak.
UC Irvine (6-8-0) defeated the No. 3 Gauchos, 1-0 on a midfielder Chris Klotz goal in the 74th minute.
No. 15 South Carolina's slide continued as the Gamecocks lost to College of Charleston, 3-0.
No. 21 Saint Louis lost to Cincinnati, 1-0.
Key matches this weekend include Stanford and California at UCLA, Duke at Virginia and VCU at Maryland.