Note: matches will be played over two legs Sept. 16 and 30, with the first team hosting the first leg.
| Aris (Greece) vs. Servette (Switzerland) |
| Red Star Belgrade (Yugoslavia) vs. Montpellier (France) |
| Inter Bratislava (Slovakia) vs. Rapid Vienna (Austria) |
| Juventus (Italy) vs. Omonia Nicosia (Cyprus) |
| Ajax Amsterdam (Netherlands) vs. Dukla (Slovakia) |
| Leeds Utd. (England) vs. Partizan Belgrade (Yugoslavia) |
| Bodoe/Glimt (Norway) vs. Werder Bremen (Germany) |
| Helsingborg (Sweden) vs. Karpaty Lviv (Ukraine) |
| Lausanne (Switzerland) vs. Celta Vigo (Spain) |
| Skonto Riga (Latvia) vs. Widzew Lodz (Poland) |
| Parma (Italy) vs. Kryvbas KR (Ukraine) |
| Wolfsburg (Germany) vs. Debrecen (Hungary) |
| Teplice (Czech Rep.) vs. Ferencvaros (Hungary) |
| Tottenham (England) vs. Zimbru Chisinau (Moldova) |
| Atletico Madrid (Spain) vs. Ankaragucu (Turkey) |
| Maccabi Tel Aviv (Israel) vs. Lens (France) |
| Beira Mar (Portugal) vs. Vitesse Arnhem (Netherlands) |
| Monaco (France) vs. St. Johnstone (Scotland) |
| Torpedo Kutaisi (Georgia) vs. AEK Athens (Greece) |
| West Ham Utd. (England) vs. Osijek (Croatia) |
| Lokomotiv Tbilisi (Georgia) vs. PAOK Salonika (Greece) |
| Amica Wronki (Poland) vs. Broendby (Denmark) |
| Roma (Italy) vs. Vitoria Setubal (Portugal) |
| Anderlecht (Belgium) vs. Olimpija Ljubljana (Slovenia) |
| Lech Poznan (Poland) vs. IFK Gothenburg (Sweden) |
| Glasgow Celtic (Scotland) vs. Hapoel Tel Aviv (Israel) |
| HJK Helsinki (Finland) vs. Lyon (France) |
| Sigma Olomouc (Czech Rep.) vs. Mallorca (Spain) |
| AB (Denmark) vs. Grasshoppers (Switzerland) |
| CSKA Sofia (Bulgaria) vs. Newcastle (England) |
| Benfica (Portugal) vs. Dinamo Bucharest (Romania) |
| MTK (Hungary) vs. Fenerbahce (Turkey) |
| Viking (Norway) vs. Sporting Lisbon (Portugal) |
| Graz AK (Austria) vs. Spartak Trnava (Slovakia) |
| Ionikos Piraeus (Greece) vs. Nantes (France) |
| Hapoel Haifa (Israel) vs. Club Bruges (Belgium) |
| Anorthosis (Cyprus) vs. Legia Warsaw (Poland) |
| Nova Gorica (Slovenia) vs. Panathinakios (Greece) |
| Steaua Bucharest (Romania) vs. LASK Linz (Austria) |
| Zenit St. Petersburg (Russia) vs. Bologna (Italy) |
| Roda JC Kerkraade (Netherlands) vs. Shakhtar Donetsk (Ukraine) |
| Kaiserslautern (Germany) vs. Kilmarnock (Scotland) |
| Hajduk Split (Croatia) vs. Levski Sofia (Bulgaria) |
| Lokomotiv Moscow (Russia) vs. Lyngby (Denmark) |
| Vojvodina (Yugoslavia) vs. Slavia Prague (Czech Rep.) |
| FC Zurich (Switzerland) vs. Lierse (Belgium) |
| Stabaek (Norway) vs. Deportivo La Coruna (Spain) |
| Udinese (Italy) vs. Aalborg (Denmark) |