The following is the 1998 Columbus Crew schedule. Please note that all times listed are eastern and everything is subject to change.
| Date | Opponent | Kickoff |
| March 21 | at Tampa Bay | 7:30 p.m. |
| March 29 | at Dallas | 3:00 p.m. |
| April 4 | D.C. United | 7:30 p.m. |
| April 11 | New England | 7:30 p.m. |
| April 18 | Miami | 7:30 p.m. |
| April 26 | at D.C. United | 3:00 p.m. |
| April 30 | at Tampa Bay | 7:30 p.m. |
| May 9 | at Miami | 4:00 p.m. |
| May 17 | Los Angeles | 3:00 p.m. |
| May 22 | at New England | 7:30 p.m. |
| May 27 | at Kansas City | 8:30 p.m. |
| May 30 | San Jose | 7:30 p.m. |
| June 6 | at Chicago | 8:00 p.m. |
| June 13 | D.C. United | 7:30 p.m. |
| June 20 | MetroStars | 7:30 p.m. |
| July 3 | at San Jose | 10:30 p.m. |
| July 9 | Chicago | 7:30 p.m. |
| July 19 | at MetroStars | 3:00 p.m. |
| July 25 | Dallas | 7:30 p.m. |
| July 29 | at Miami | 7:30 p.m. |
| Aug. 8 | New England | 7:00 p.m. |
| Aug. 12 | at MetroStars | 7:30 p.m. |
| Aug. 16 | Kansas City | 3:00 p.m. |
| Aug. 22 | Tampa Bay | 7:30 p.m. |
| Aug. 29 | at Los Angeles | 10:30 p.m. |
| Sept. 6 | MetroStars | 3:00 p.m. |
| Sept. 9 | Miami | 7:30 p.m. |
| Sept. 12 | at New England | 7:30 p.m. |
| Sept. 16 | Colorado | 7:30 p.m. |
| Sept. 19 | at Colorado | 9:00 p.m. |
| Sept. 24 | Tampa Bay | 8:00 p.m. |
| Sept. 27 | at D.C. United | 5:00 p.m. |