Here is the 1999 Miami Fusion schedule. Please note that all times are ET and that the schedule is subject to change.
| Date | Opponent | Time (ET) |
| Sat. March 20 | MetroStars | 8:00 p.m. |
| Sun. March 28 | New England | 3:00 p.m. |
| Sat. April 3 | Chicago | 7:00 p.m. |
| Sat. April 10 | at Colorado | 9:00 p.m. |
| Thu. April 15 | Dallas | 8:00 p.m. |
| Sat. April 24 | Kansas City | 7:30 p.m. |
| Sat. May 1 | at Tampa Bay | 7:00 p.m. |
| Sat. May 8 | at New England | 7:30 p.m. |
| Sat. May 15 | at MetroStars | 7:00 p.m. |
| Sat. May 22 | D.C. United | 2:00 p.m. |
| Wed. May 26 | at Dallas | 8:30 p.m. |
| Sat. May 29 | Tampa Bay | 7:30 p.m. |
| Sat. June 5 | at Tampa Bay | 7:00 p.m. |
| Thu. June 10 | at D.C. United | 7:30 p.m. |
| Sun. June 13 | at New England | 4:00 p.m. |
| Sat. June 26 | San Jose | 7:30 p.m. |
| Sun. July 4 | at Los Angeles | 10:30 p.m. |
| Sat. July 10 | Columbus | 7:30 p.m. |
| Sat. July 24 | at MetroStars | 3:00 p.m. |
| Thu. July 29 | Tampa Bay | 7:30 p.m. |
| Sun. Aug. 1 | at Columbus | 1:00 p.m. |
| Sat. Aug. 7 | MetroStars | 7:30 p.m. |
| Sat. Aug. 14 | at Chicago | 8:30 p.m. |
| Sat. Aug. 21 | D.C. United | 8:00 p.m. |
| Wed. Aug. 25 | at D.C. United | 7:30 p.m. |
| Sun. Aug. 29 | at Kansas City | 1:00 p.m. |
| Sat. Sept. 4 | Los Angeles | 7:30 p.m. |
| Sat. Sept. 11 | New England | 7:30 p.m. |
| Sun. Sept. 19 | at San Jose | 5:00 p.m. |
| Sun. Sept. 26 | at Columbus | 1:00 p.m. |
| Sun. Oct. 3 | Columbus | 7:30 p.m. |
| Sat. Oct. 9 | Colorado | 7:30 p.m. |