The following changes have been made to the 1999 MLS regular-season schedule:
| Matchup | Old Date & Time (ET) | New Date & Time (ET) |
| Colorado at Los Angeles | March 21 at 7:30 p.m. | March 20 at 10:30 p.m. |
| Colorado at San Jose | March 27 at 10:30 p.m. | March 27 at 10:00 p.m. |
| Los Angeles at San Jose | April 3 at 10:30 p.m. | April 3 at 10:00 p.m. |
| San Jose at Kansas City | April 10 at 4:30 p.m. | April 10 at 3:30 p.m. |
| Dallas at Miami | April 15 at 7:30 p.m. | April 15 at 8:00 p.m. |
| Dallas at San Jose | May 22 at 10:30 p.m. | May 22 at 11:00 p.m. |
| Chicago at D.C. United | May 30 at 3:30 p.m. | May 29 at 7:30 p.m. |
| MetroStars at Chicago | July 10 at 8:00 p.m. | July 10 at 8:30 p.m. |
| Los Angeles at Colorado | July 21 at 9:00 p.m. | July 28 at 9:00 p.m. |
| D.C. United at Miami | Aug. 21 at 7:30 p.m. | Aug. 21 at 8:00 p.m. |
| New England at Chicago | Aug. 28 at 1:00 p.m. | Aug. 28 at 8:00 p.m. |