The winner of the USA-Mexico qualifier will clinch a berth in the 2006 World Cup finals. Mexico will qualify in case of a tie, but there are scenarios by which both teams will qualify, regardless of the outcome of the Columbus game.

USA
USA will qualify for the finals if:
1. USA beats Mexico.
2. USA ties Mexico AND Panama beats or ties Costa Rica AND Trinidad & Tobago beats or ties Guatemala.
3. USA loses to Mexico AND Panama beats Costa Rica AND Trinidad & Tobago ties Guatemala.

MEXICO
Mexico will qualify if:
1. Mexico beats USA.
2. Mexico ties USA
3. Mexico loses to USA AND Panama beats Costa Rica.
4. Mexico loses to USA AND Panama ties Costa Rica AND Trinidad & Tobago beats or ties Guatemala.